Abnormalities of plasma von Willebrand factor multimeric structure induced by extracorporeal circulation.

نویسندگان

  • P Perutelli
  • F Lerzo
  • G Calza
  • M Cevasco
  • P G Mori
چکیده

chio M, Porta F. Rapid regeneration of normally functional naive CD4+ T-cells after bone marrow transplantation from unrelated donors for combined immunodeficiency. Blood 1998; 92:3484-6. 7. Mackall CL, Hakim FT, Gress RE. T-cell regeneration: all repertoires are not created equal. Immunol Today 1997; 18:245-51. 8. Dickinson AM, Reid MM, Abinum M, et al. In vitro T cell depletion using Campath 1M for mismatched BMT for severe combined immunodeficiency (SCID). Bone Marrow Transplant 1997; 19:323-9. 9. Brugnoni D, Airò P, Pennacchio M, et al. Immune reconstitution after bone marrow transplantation for combined immunodeficiencies: down-modulation of Bcl-2 and high expression of CD95/Fas account for increased susceptibility to spontaneous and activation-induced lymphocyte cell death. Bone Marrow Transplant (in press). 10. Porta F, Mazzolari E, Lanfranchi A, Pennacchio M, Fischer A. Immunological reconstitution after bone marrow transplantation. Bone Marrow Transplant 1996; 18 (Suppl. 2):148-50.

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Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand's disease subtypes.

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Type IIB von Willebrand's disease: differential clearance of endogenous versus transfused large multimer von willebrand factor.

The abnormal multimeric composition of plasma von Willebrand factor in type IIB von Willebrand's disease is transiently corrected after infusion of 1-deamino-[8-D-arginine]-vasopressin. However, the larger multimers released into the circulation disappear more rapidly in these patients than in type I von Willebrand's disease or normals. We demonstrate that the larger multimers of normal von Wil...

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Improvement of von Willebrand factor proteolysis after prostacyclin infusion in severe pulmonary arterial hypertension.

BACKGROUND The presence of dysfunctional von Willebrand factor (vWF) in pulmonary arterial hypertension (PAH) was suggested to be related to increased proteolysis. METHODS AND RESULTS In 10 patients with severe PAH, we studied the proteolysis of plasma vWF (vWF levels, multimeric distribution, proteolytic pattern, and cleaving protease activity) and hemodynamic variables (mean pulmonary arter...

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Variant von Willebrand's disease: characterization of two subtypes by analysis of multimeric composition of factor VIII/von Willebrand factor in plasma and platelets.

We have examined the multimeric composition of factor VIII/von Willebrand factor in plasma and platelet lysates by means of sodium dodecyl sulfate agarose electrophoresis followed by staining with (125)I-labeled affinity-purified antibody. In normal plasma and platelet lysates, factor VIII/von Willebrand factor displayed 10 distinct multimers that ranged in apparent molecular weight from 0.86 t...

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عنوان ژورنال:
  • Haematologica

دوره 84 3  شماره 

صفحات  -

تاریخ انتشار 1999